RAF Typhoon jets have operated alongside France's air force in a coordinated attack on an hidden munitions depot in Syrian territory employed by the IS group, according to the UK Ministry of Defence.
The site, located using surveillance, was assessed as storing arms and explosives, the release indicated, and was situated in mountainous terrain just to the north of the ancient city of Palmyra in central Syria.
"Our fighter planes used laser-guided Paveway IV weapons to strike a several approach shafts down to the site... early reports are that the strike was effective," the MoD said.
There was no evidence of any harm to civilians in the strike late on Saturday and every plane involved returned safely, the MoD added.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
The Islamic State group - referred to as Daesh - established extremist governance over significant areas in Iraq and Syria until 2019.
"This action demonstrates British leadership, and determination to stand shoulder to shoulder with our allies, to stamp out any resurgence of Daesh and their violent and radical beliefs in the area," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have performed patrols over Syrian airspace to "prevent any attempted comeback" of IS following its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank the personnel of British forces who took part in this mission for their skill and their bravery," he added. "They were part of a great many British troops on duty over the holidays. This action, to eliminate dangerous terrorists who pose a risk to our security, highlights how UK forces are prepared to act, continuously, ensuring Britain's security within its borders and influential overseas."
In December, the US military executed what it called a "large-scale strike" targeting IS targets in Syria, following an ambush claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The U.N. reports Daesh still maintains between 5,000 and 7,000 fighters in Syria and Iraq.